A GSH-activatable ruthenium(II)-azo photosensitizer for two-photon photodynamic therapy

Leli Zeng; Shi Kuang; Guanying Li; Chengzhi Jin; Liangnian Ji; Hui Chao

doi:10.1039/C6CC10330H

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A GSH-activatable ruthenium(ii)-azo photosensitizer for two-photon photodynamic therapy†

Leli Zeng,‡^a Shi Kuang,‡^a Guanying Li,^a Chengzhi Jin,^a Liangnian Ji^a and Hui Chao

*^a

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* Corresponding authors

^a MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China
E-mail: ceschh@mail.sysu.edu.cn

Abstract

A glutathione (GSH)-activatable ruthenium(II)-azo photosensitizer was prepared. The complex had low toxicity towards cells under dark conditions. It exhibited excellent phototoxicity under two-photon excitation (810 nm) and thus was developed as a two-photon photodynamic anticancer agent for cancer therapy.

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Article information

DOI: https://doi.org/10.1039/C6CC10330H
Article type: Communication
Submitted: 31 Dec 2016
Accepted: 18 Jan 2017
First published: 19 Jan 2017

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Chem. Commun., 2017,53, 1977-1980

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A GSH-activatable ruthenium(II)-azo photosensitizer for two-photon photodynamic therapy

L. Zeng, S. Kuang, G. Li, C. Jin, L. Ji and H. Chao, Chem. Commun., 2017, 53, 1977 DOI: 10.1039/C6CC10330H

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Chemical Communications

A GSH-activatable ruthenium(ii)-azo photosensitizer for two-photon photodynamic therapy†

Abstract

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A GSH-activatable ruthenium(II)-azo photosensitizer for two-photon photodynamic therapy

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