Crosslinked shells for nano-assembled capsules: a new encapsulation method for smaller Gd3+-loaded capsules with exceedingly high relaxivities

Annah Farashishiko; Sally E. Plush; Karley B. Maier; A. Dean Sherry; Mark Woods

doi:10.1039/C7CC00123A

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Crosslinked shells for nano-assembled capsules: a new encapsulation method for smaller Gd³⁺-loaded capsules with exceedingly high relaxivities†

Annah Farashishiko,^a Sally E. Plush,

^b Karley B. Maier,

^a A. Dean Sherry

^cd and Mark Woods

*^ae

Author affiliations

* Corresponding authors

^a Department of Chemistry, Portland State University, 1719 SW 10th Ave, Portland, OR 97201, USA
E-mail: mark.woods@pdx.edu

^b Sansom Institute for Health Research, University of South Australia, GPO Box 2471, Adelaide, South Australia 5001, Australia

^c Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA

^d Department of Chemistry, University of Texas at Dallas, 800 W Campbell Road, Richardson, TX 75080, USA

^e Advanced Imaging Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
E-mail: woodsmar@ohsu.edu

Abstract

Nano-assembled capsules can incorporate large payloads of high relaxivity Gd³⁺, permitting the development of highly detectable molecular imaging agents for MRI. A new encapsulating shell, based upon cross-linked peptides, is found to afford smaller capsules (127 nm average diameter) with exceptionally high per-Gd³⁺ relaxivities (70.7 s⁻¹ mmolal⁻¹).

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Article information

DOI: https://doi.org/10.1039/C7CC00123A
Article type: Communication
Submitted: 06 Jan 2017
Accepted: 23 May 2017
First published: 30 May 2017

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Chem. Commun., 2017,53, 6355-6358

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Crosslinked shells for nano-assembled capsules: a new encapsulation method for smaller Gd³⁺-loaded capsules with exceedingly high relaxivities

A. Farashishiko, S. E. Plush, K. B. Maier, A. Dean Sherry and M. Woods, Chem. Commun., 2017, 53, 6355 DOI: 10.1039/C7CC00123A

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