Issue 19, 2017

Regioselective synthesis of difluoroalkyl/perfluoroalkyl enones via Pd-catalyzed four-component carbonylative coupling reactions

Abstract

The first example of Pd-catalyzed four-component carbonylative difluoroalkylation/perfluoroalkylation through the alkyne difunctionalization process is achieved. The reaction proceeds smoothly under mild conditions in the presence of 1 atm of CO at room temperature with good yields and E-selectivities. The utilization of CsF as an additive is vital to the success of the reaction.

Graphical abstract: Regioselective synthesis of difluoroalkyl/perfluoroalkyl enones via Pd-catalyzed four-component carbonylative coupling reactions

Supplementary files

Article information

Article type
Communication
Submitted
11 Jan 2017
Accepted
13 Feb 2017
First published
13 Feb 2017

Chem. Commun., 2017,53, 2814-2817

Regioselective synthesis of difluoroalkyl/perfluoroalkyl enones via Pd-catalyzed four-component carbonylative coupling reactions

Q. Wang, L. Zheng, Y. He and Y. Liang, Chem. Commun., 2017, 53, 2814 DOI: 10.1039/C7CC00259A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements