Unprecedented highly efficient capture of glycopeptides by Fe3O4@Mg-MOF-74 core–shell nanoparticles

Jie Li; Jiaxi Wang; Yun Ling; Zhenxia Chen; Mingxia Gao; Xiangmin Zhang; Yaming Zhou

doi:10.1039/C7CC00447H

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Unprecedented highly efficient capture of glycopeptides by Fe₃O₄@Mg-MOF-74 core–shell nanoparticles†

Jie Li,^a Jiaxi Wang,^b Yun Ling,

*^a Zhenxia Chen,^a Mingxia Gao,^b Xiangmin Zhang

^b and Yaming Zhou*^a

Author affiliations

* Corresponding authors

^a Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai, China
E-mail: yunling@fudan.edu.cn, ymzhou@fudan.edu.cn

^b Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China

Abstract

Magnetic Fe₃O₄ nanospheres coated with Mg-MOF-74 have been facilely prepared via epitaxial growth. Owing to the intrinsic hydrophilic pore surface and size-exclusive properties of Mg-MOF-74, the Fe₃O₄@Mg-MOF-74 core–shell nanoparticles show effective and selective enrichment of 441 N-glycosylation sites of 418 glycopeptides from 125 glycoproteins in 1 μL of human serum.

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Article information

DOI: https://doi.org/10.1039/C7CC00447H
Article type: Communication
Submitted: 18 Jan 2017
Accepted: 15 Mar 2017
First published: 24 Mar 2017

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Chem. Commun., 2017,53, 4018-4021

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Unprecedented highly efficient capture of glycopeptides by Fe₃O₄@Mg-MOF-74 core–shell nanoparticles

J. Li, J. Wang, Y. Ling, Z. Chen, M. Gao, X. Zhang and Y. Zhou, Chem. Commun., 2017, 53, 4018 DOI: 10.1039/C7CC00447H

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