Issue 17, 2017

Pd/Cu cooperative catalysis: an efficient synthesis of (3-isoindazolyl)allenes via cross-coupling of 2-alkynyl azobenzenes and terminal alkynes

Abstract

An efficient synthesis of (3-isoindazolyl)allenes from 2-alkynyl azobenzenes and terminal alkynes via cooperative Pd(PPh3)2Cl2/CuI-catalyzed cross-coupling has been developed. By making use of this approach, (3-isoindazolyl)allenes with various substituents can be synthesized in good to excellent yields. A rapid synthesis of biologically active indazolo[2,3-a]quinoline was also achieved using this method as the key step.

Graphical abstract: Pd/Cu cooperative catalysis: an efficient synthesis of (3-isoindazolyl)allenes via cross-coupling of 2-alkynyl azobenzenes and terminal alkynes

Supplementary files

Article information

Article type
Communication
Submitted
20 Jan 2017
Accepted
03 Feb 2017
First published
03 Feb 2017

Chem. Commun., 2017,53, 2606-2609

Pd/Cu cooperative catalysis: an efficient synthesis of (3-isoindazolyl)allenes via cross-coupling of 2-alkynyl azobenzenes and terminal alkynes

C. Zhu, C. Feng and M. Yamane, Chem. Commun., 2017, 53, 2606 DOI: 10.1039/C7CC00562H

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