Issue 23, 2017

A new and potentially prebiotic α-cytidine derivative

Abstract

A new α-cytidine derivative was synthesised from the prebiotic reaction of ribose aminooxazoline and dicyanoacetylene. The tetracyclic structure of the product was confirmed by X-ray diffraction and then an alternative 6-step synthetic pathway to the product was found which was suitable for large-scale synthesis.

Graphical abstract: A new and potentially prebiotic α-cytidine derivative

Supplementary files

Article information

Article type
Communication
Submitted
24 Jan 2017
Accepted
15 Feb 2017
First published
23 Feb 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 3327-3329

A new and potentially prebiotic α-cytidine derivative

M. Tsanakopoulou, J. Xu, A. D. Bond and J. D. Sutherland, Chem. Commun., 2017, 53, 3327 DOI: 10.1039/C7CC00693D

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