Solid-phase synthesis of peptide selenoesters via a side-chain anchoring strategy†
Cameron C.
Hanna, 
a
Sameer S.
Kulkarni,
a
Emma E.
Watson,
a
Bhavesh
Premdjee
a
and
Richard J.
Payne
*a
a
Sameer S.
Kulkarni,
a
Emma E.
Watson,
a
Bhavesh
Premdjee
a
and
Richard J.
Payne
*a
Abstract
Peptide selenoesters have recently emerged as key building blocks for the ligation-based assembly of large polypeptides and proteins. Herein, we report an efficient solid-phase method for the high yielding and epimerisation-free synthesis of peptide selenoesters using a side-chain immobilisation strategy.
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