Issue 26, 2017

Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1

Abstract

New Ru(II)-caged abiraterone complexes were synthesized that exhibit strong absorption in the visible region and release the steroidal CYP17A1 inhibitor abiraterone upon exposure to low energy visible light in buffer and prostate cancer cells. Photoinduced release results in abiraterone binding to its CYP17A1 target in an inhibitory mode.

Graphical abstract: Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1

Supplementary files

Article information

Article type
Communication
Submitted
23 Feb 2017
Accepted
07 Mar 2017
First published
07 Mar 2017

Chem. Commun., 2017,53, 3673-3676

Illuminating cytochrome P450 binding: Ru(II)-caged inhibitors of CYP17A1

A. Li, R. Yadav, J. K. White, M. K. Herroon, B. P. Callahan, I. Podgorski, C. Turro, E. E. Scott and J. J. Kodanko, Chem. Commun., 2017, 53, 3673 DOI: 10.1039/C7CC01459G

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