Issue 35, 2017

Cyclic ether synthesis from diols using trimethyl phosphate

Abstract

Cyclic ethers have been effectively synthesized via the intramolecular cyclization of diols using trimethyl phosphate and NaH. The present cyclization could proceed at room temperature to produce 5–7 membered cyclic ethers in good to excellent yields. Substrates possessing a chiral secondary hydroxy group were transformed into the corresponding chiral cyclic ethers along with the retention of their stereochemistries.

Graphical abstract: Cyclic ether synthesis from diols using trimethyl phosphate

Supplementary files

Article information

Article type
Communication
Submitted
27 Feb 2017
Accepted
05 Apr 2017
First published
06 Apr 2017

Chem. Commun., 2017,53, 4787-4790

Cyclic ether synthesis from diols using trimethyl phosphate

S. Asai, M. Kato, Y. Monguchi, H. Sajiki and Y. Sawama, Chem. Commun., 2017, 53, 4787 DOI: 10.1039/C7CC01514C

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