Somatostatin receptor-targeted organometallic iridium(III) complexes as novel theranostic agents

Vojtech Novohradsky; Ana Zamora; Albert Gandioso; Viktor Brabec; José Ruiz; Vicente Marchán

doi:10.1039/C7CC01946G

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Somatostatin receptor-targeted organometallic iridium(iii) complexes as novel theranostic agents†

Vojtech Novohradsky,^a Ana Zamora,^bc Albert Gandioso,^b Viktor Brabec,

*^a José Ruiz

*^c and Vicente Marchán

*^b

Author affiliations

* Corresponding authors

^a Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i. Kralovopolska 135, 612 65 Brno, Czech Republic
E-mail: brabec@ibp.cz

^b Departament de Química Inorgànica i Orgànica, Secció de Química Orgànica, IBUB, Universitat de Barcelona, E-08028 Barcelona, Spain
E-mail: vmarchan@ub.edu

^c Departamento de Química Inorgánica, Universidad de Murcia, and Institute for Bio-Health Research of Murcia (IMIB-Arrixaca), E-30071 Murcia, Spain
E-mail: jruiz@um.es

Abstract

A novel somatostatin receptor-targeted anticancer agent based on the conjugation of a highly cytotoxic and luminescent cyclometalated iridium(III) complex to tumor-targeting vectors based on octreotide peptide has been described, and its potential for targeted theranostic applications has been demonstrated.

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Article information

DOI: https://doi.org/10.1039/C7CC01946G
Article type: Communication
Submitted: 14 Mar 2017
Accepted: 23 Apr 2017
First published: 25 Apr 2017
This article is Open Access

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Chem. Commun., 2017,53, 5523-5526

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Somatostatin receptor-targeted organometallic iridium(III) complexes as novel theranostic agents

V. Novohradsky, A. Zamora, A. Gandioso, V. Brabec, J. Ruiz and V. Marchán, Chem. Commun., 2017, 53, 5523 DOI: 10.1039/C7CC01946G

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Chemical Communications

Somatostatin receptor-targeted organometallic iridium(iii) complexes as novel theranostic agents†

Abstract

Supplementary files

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Somatostatin receptor-targeted organometallic iridium(III) complexes as novel theranostic agents

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