Issue 45, 2017
From the journal:

Chemical Communications

Lanthanoplatins: emissive Eu(iii) and Tb(iii) complexes staining nucleoli targeted through Pt–DNA crosslinking†

Khushbu Singh,a   Swati Singh,b   Payal Srivastava,a   Sri Sivakumar ORCID logo b  and  Ashis K. Patra ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, Uttar Pradesh, India
E-mail: akpatra@iitk.ac.in

b Department of Chemical Engineering and Centre for Environmental Science and Engineering, Indian Institute of Technology Kanpur, Kanpur 208016, Uttar Pradesh, India

Abstract

Two highly luminescent water-soluble heterometallic LnPt2 complexes, [{cis-PtCl(NH3)2}2Ln(L)(H2O)](NO3)2 (Ln = Eu (1), Tb (2)), have been designed for their selective nucleoli staining through formation of Pt–DNA crosslinks. The complexes showed significant cellular uptake and distinctive nucleoli localization through intrinsic emission from EuIII or TbIII observed through confocal fluorescence microscopy.

Graphical abstract: Lanthanoplatins: emissive Eu(iii) and Tb(iii) complexes staining nucleoli targeted through Pt–DNA crosslinking

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Article information

DOI
https://doi.org/10.1039/C7CC02047C
Article type
Communication
Submitted
17 Mar 2017
Accepted
12 May 2017
First published
12 May 2017

Chem. Commun., 2017,53, 6144-6147

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Lanthanoplatins: emissive Eu(III) and Tb(III) complexes staining nucleoli targeted through Pt–DNA crosslinking

K. Singh, S. Singh, P. Srivastava, S. Sivakumar and A. K. Patra, Chem. Commun., 2017, 53, 6144 DOI: 10.1039/C7CC02047C

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