Issue 39, 2017

Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies

Abstract

We describe here the synthesis of novel multivalent HIV V3 domain glycopeptides and their binding to broadly neutralizing antibodies PGT128 and 10-1074. Our binding data reveal a distinct mode of antigen recognition by the two antibodies and further suggest that multivalent glycopeptides could mimic the neutralizing epitopes more efficiently than the monomeric glycopeptide.

Graphical abstract: Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies

Supplementary files

Article information

Article type
Communication
Submitted
17 Mar 2017
Accepted
23 Apr 2017
First published
25 Apr 2017

Chem. Commun., 2017,53, 5453-5456

Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies

H. Cai, J. Orwenyo, J. Guenaga, J. Giddens, C. Toonstra, R. T. Wyatt and L. Wang, Chem. Commun., 2017, 53, 5453 DOI: 10.1039/C7CC02059G

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