Inhibition of D-Ala incorporation into wall teichoic acid in Staphylococcus aureus by desleucyl-oritavancin

J. Chang; L. Coffman; S. J. Kim

doi:10.1039/C7CC02635H

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Inhibition of d-Ala incorporation into wall teichoic acid in Staphylococcus aureus by desleucyl-oritavancin†

J. Chang,^a L. Coffman^a and S. J. Kim

*^a

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* Corresponding authors

^a Department of Chemistry, Baylor University, One Bear Place #97348, Waco, Texas 76798, USA
E-mail: Sung_J_Kim@baylor.edu
Tel: +1-254-710-2531

Abstract

The mode of action for desleucyl-oritavancin was investigated by adding an antibiotic to Staphylococcus aureus during its growth in a defined medium containing L,D-[1-¹⁵N]Ala and L-[1-¹³C]Lys, or D-[1-¹⁵N]Ala. ¹³C{¹⁵N} and ¹⁵N{¹³C} rotational-echo double resonance NMR determined that desleucyl-oritavancin inhibited the incorporation of D-[1-¹⁵N]Ala into wall teichoic acid.

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Article information

DOI: https://doi.org/10.1039/C7CC02635H
Article type: Communication
Submitted: 05 Apr 2017
Accepted: 03 May 2017
First published: 03 May 2017

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Chem. Commun., 2017,53, 5649-5652

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Inhibition of D-Ala incorporation into wall teichoic acid in Staphylococcus aureus by desleucyl-oritavancin

J. Chang, L. Coffman and S. J. Kim, Chem. Commun., 2017, 53, 5649 DOI: 10.1039/C7CC02635H

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Chemical Communications

Inhibition of d-Ala incorporation into wall teichoic acid in Staphylococcus aureus by desleucyl-oritavancin†

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Inhibition of D-Ala incorporation into wall teichoic acid in Staphylococcus aureus by desleucyl-oritavancin

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