Issue 48, 2017
From the journal:

Chemical Communications

A smart drug: a pH-responsive photothermal ablation agent for Golgi apparatus activated cancer therapy†

Fengfeng Xue,a   Ying Wen,a   Peng Wei,a   Yilin Gao,a   Zhiguo Zhou,b   Shuzhang Xiaoc  and  Tao Yi ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, 220 Handan Road, Shanghai 200433, China
E-mail: yitao@fudan.edu.cn

b The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, China

c Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Hubei 443002, China

Abstract

We report a pH-responsive photothermal ablation agent (pH-PTT) based on cyanine dyes for photothermal therapy (PTT). The nanoparticles formed by BSA and pH-PTT preferentially accumulated in the Golgi apparatus of cancer cells compared to normal cells, and thus can be specifically activated by the acidic Golgi apparatus in cancer cells for effective PTT both ex vivo and in vivo.

Graphical abstract: A smart drug: a pH-responsive photothermal ablation agent for Golgi apparatus activated cancer therapy

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Article information

DOI
https://doi.org/10.1039/C7CC03168H
Article type
Communication
Submitted
25 Apr 2017
Accepted
22 May 2017
First published
22 May 2017

Chem. Commun., 2017,53, 6424-6427

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A smart drug: a pH-responsive photothermal ablation agent for Golgi apparatus activated cancer therapy

F. Xue, Y. Wen, P. Wei, Y. Gao, Z. Zhou, S. Xiao and T. Yi, Chem. Commun., 2017, 53, 6424 DOI: 10.1039/C7CC03168H

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