Elucidation of the elusive structure and formula of the active pharmaceutical ingredient bismuth subgallate by continuous rotation electron diffraction

Yunchen Wang; Sofia Takki; Ocean Cheung; Hongyi Xu; Wei Wan; Lars Öhrström; A. Ken Inge

doi:10.1039/C7CC03180G

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Elucidation of the elusive structure and formula of the active pharmaceutical ingredient bismuth subgallate by continuous rotation electron diffraction†

Yunchen Wang,^a Sofia Takki,^a Ocean Cheung,^b Hongyi Xu,^a Wei Wan,^a Lars Öhrström

^c and A. Ken Inge

*^a

Author affiliations

* Corresponding authors

^a Department of Material and Environmental Chemistry, Stockholm University, 106 91 Stockholm, Sweden
E-mail: andrew.inge@mmk.su.se

^b School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, UK

^c Department of Chemistry and Chemical Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden

Abstract

Bismuth subgallate has been used in wound and gastrointestinal therapy for over a century. The combination of continuous rotation electron diffraction and sample cooling finally revealed its structure as a coordination polymer. The structure provides insight regarding its formula, poor solubility, acid resistance and previously unreported gas sorption properties.

$Graphical abstract: Elucidation of the elusive structure and formula of the active pharmaceutical ingredient bismuth subgallate by continuous rotation electron diffraction$

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DOI: https://doi.org/10.1039/C7CC03180G
Article type: Communication
Submitted: 25 Apr 2017
Accepted: 07 Jun 2017
First published: 07 Jun 2017
This article is Open Access

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Chem. Commun., 2017,53, 7018-7021

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Elucidation of the elusive structure and formula of the active pharmaceutical ingredient bismuth subgallate by continuous rotation electron diffraction

Y. Wang, S. Takki, O. Cheung, H. Xu, W. Wan, L. Öhrström and A. K. Inge, Chem. Commun., 2017, 53, 7018 DOI: 10.1039/C7CC03180G

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Chemical Communications

Elucidation of the elusive structure and formula of the active pharmaceutical ingredient bismuth subgallate by continuous rotation electron diffraction†

Abstract

Supplementary files

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Elucidation of the elusive structure and formula of the active pharmaceutical ingredient bismuth subgallate by continuous rotation electron diffraction

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