Issue 59, 2017

Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery

Abstract

This study introduces a novel class of imidazolium- and ammonium-based ionic liquids possessing two C12 and C14 tails and thioether linkers designed for lipoplex-mediated DNA delivery. Imidazolium-based ionic liquids displayed efficient gene delivery properties with low toxicity. Thiol–yne click chemistry was employed for the facile and robust synthesis of these thioether-based cationic lipioids with enhanced lipophilicity and low fluidity.

Graphical abstract: Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery

Supplementary files

Article information

Article type
Communication
Submitted
26 Apr 2017
Accepted
04 Jul 2017
First published
04 Jul 2017

Chem. Commun., 2017,53, 8328-8331

Ionic liquids with thioether motifs as synthetic cationic lipids for gene delivery

J. C. Gaitor, L. M. Paul, M. M. Reardon, T. Hmissa, S. Minkowicz, M. Regner, Y. Sheng, S. F. Michael, S. Isern and A. Mirjafari, Chem. Commun., 2017, 53, 8328 DOI: 10.1039/C7CC03235H

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