Issue 54, 2017

Nucleopolypeptides with DNA-triggered α helix-to-β sheet transition

Abstract

Synthetic polypeptides are versatile polymers outstandingly relevant to prepare bioinspired materials. In this work, we present a new class of smart polypeptide polymers, called nucleopolypeptides, having lateral chains functionalized with thymidine nucleobases. Structural studies performed by circular dichroism have revealed that the secondary structure of the polymers was influenced by nucleotide interaction and DNA sequence variation affording a selective helix-to-beta sheet transition with oligo(AAAAA)6.

Graphical abstract: Nucleopolypeptides with DNA-triggered α helix-to-β sheet transition

Supplementary files

Article information

Article type
Communication
Submitted
04 May 2017
Accepted
07 Jun 2017
First published
07 Jun 2017

Chem. Commun., 2017,53, 7501-7504

Nucleopolypeptides with DNA-triggered α helix-to-β sheet transition

M. Nguyen, J. Stigliani, G. Pratviel and C. Bonduelle, Chem. Commun., 2017, 53, 7501 DOI: 10.1039/C7CC03472E

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