Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89

L. Allott; C. Da Pieve; J. Meyers; T. Spinks; D. M. Ciobota; G. Kramer-Marek; G. Smith

doi:10.1039/C7CC03572A

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Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89†

L. Allott,

‡^a C. Da Pieve,‡^a J. Meyers,

^b T. Spinks,^a D. M. Ciobota,^a G. Kramer-Marek

^a and G. Smith

*^a

Author affiliations

* Corresponding authors

^a Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, UK
E-mail: graham.smith@icr.ac.uk

^b Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, 123 Old Brompton Road, London, UK

Abstract

The future of ⁸⁹Zr-based immuno-PET is reliant upon the development of new chelators with improved stability compared to the currently used deferoxamine (DFO). Herein, we report the evaluation of the octadentate molecule DFO-HOPO (3) as a suitable chelator for ⁸⁹Zr and a more stable alternative to DFO. The molecule showed good potential for the future development of a DFO-HOPO-based bifunctional chelator (BFC) for the radiolabelling of biomolecules with ⁸⁹Zr. This work broadens the selection of available chelators for ⁸⁹Zr in search of improved successors to DFO for clinical ⁸⁹Zr-immuno-PET.

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DOI: https://doi.org/10.1039/C7CC03572A
Article type: Communication
Submitted: 08 May 2017
Accepted: 07 Jul 2017
First published: 12 Jul 2017
This article is Open Access

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Chem. Commun., 2017,53, 8529-8532

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Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89

L. Allott, C. Da Pieve, J. Meyers, T. Spinks, D. M. Ciobota, G. Kramer-Marek and G. Smith, Chem. Commun., 2017, 53, 8529 DOI: 10.1039/C7CC03572A

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Chemical Communications

Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89†

Abstract

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Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89

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