Controllable porosity conversion of metal-organic frameworks composed of natural ingredients for drug delivery

Jiang Liu; Tian-Yi Bao; Xi-Ya Yang; Pei-Pei Zhu; Lian-He Wu; Jing-Quan Sha; Lei Zhang; Long-Zhang Dong; Xue-Li Cao; Ya-Qian Lan

doi:10.1039/C7CC03673F

Controllable porosity conversion of metal-organic frameworks composed of natural ingredients for drug delivery†

Jiang Liu,‡^ab Tian-Yi Bao,‡^c Xi-Ya Yang,^a Pei-Pei Zhu,^a Lian-He Wu,^d Jing-Quan Sha,

*^ad Lei Zhang,^b Long-Zhang Dong,

^b Xue-Li Cao^b and Ya-Qian Lan

*^b

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* Corresponding authors

^a Key Laboratory of Inorganic Chemistry in Universities of Shandong, Department of Chemistry and Chemical Engineering, Jining University, Qufu, Shandong, P. R. China
E-mail: shajq2002@126.com

^b Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China
E-mail: yqlan@njnu.edu.cn

^c The Second Hospital of Jilin University, Changchun, P. R. China

^d The Provincial Key Laboratory of Biological Medicine Formulation, School of Pharmacy, Jiamusi University, Heilongjiang, Jiamusi, P. R. China

Abstract

Two extremely rare β-cyclodextrin (β-CD) supported metal-organic frameworks (MOFs), CD-MOF-1 and CD-MOF-2, were induced to crystallize for the first time through a template-induced approach. The targeted CD-MOFs were employed to perform controlled drug delivery and cytotoxicity assays that confirmed their favourable biological potential of being used as drug carriers.

Chemical Communications

Controllable porosity conversion of metal-organic frameworks composed of natural ingredients for drug delivery†

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Controllable porosity conversion of metal-organic frameworks composed of natural ingredients for drug delivery

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