Issue 58, 2017
From the journal:

Chemical Communications

A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior†‡

NIcholas T. Jacob,§a   Kensaku Anraku,§ab   Atsushi Kimishima,a   Bin Zhou,a   Karen C. Collins,a   Jonathan W. Lockner,a   Beverley A. Ellisa  and  Kim D. Janda ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Department of Immunology and Microbial Science, The Skaggs Institute for Chemical Biology, The Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA
E-mail: kdjanda@scripps.edu

b Department of Medical Technology, Kumamoto Health Science University, 325 Izumi-machi, Kita-ku, Kumamoto 861-5598, Japan

Abstract

A method for potentiating the response to an anti-cocaine vaccine by leveraging xenoreactive antibodies against the carbohydrate epitope Galα1,3-Gal (GAL) was found to result in a highly specific anti-cocaine response that was able to significantly attenuate cocaine-induced locomotion at 20 mg kg−1 with superior efficacy compared to a standard conjugate.

Graphical abstract: A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior

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Article information

DOI
https://doi.org/10.1039/C7CC04055E
Article type
Communication
Submitted
25 May 2017
Accepted
24 Jun 2017
First published
27 Jun 2017

Chem. Commun., 2017,53, 8156-8159

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A bioconjugate leveraging xenoreactive antibodies to alleviate cocaine-induced behavior

N. T. Jacob, K. Anraku, A. Kimishima, B. Zhou, K. C. Collins, J. W. Lockner, B. A. Ellis and K. D. Janda, Chem. Commun., 2017, 53, 8156 DOI: 10.1039/C7CC04055E

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