Issue 68, 2017

Palladium-catalyzed aminocarbonylation of halo-substituted 7-azaindoles and other heteroarenes using chloroform as a carbon monoxide source

Abstract

A palladium-catalyzed aminocarbonylation of halo-substituted 7-azaindoles utilizing CHCl3 as the carbonyl source has been developed for the straightforward incorporation of an amide functional group. The protocol was extended to other heteroarenes such as pyrazolopyridines and indazoles. The substrate scope of the reaction with respect to heteroarenes and the amine component is reported. This method offers an alternative avenue for aminocarbonylation of pharmaceutically important heterocycles.

Graphical abstract: Palladium-catalyzed aminocarbonylation of halo-substituted 7-azaindoles and other heteroarenes using chloroform as a carbon monoxide source

Supplementary files

Article information

Article type
Communication
Submitted
05 Jun 2017
Accepted
02 Aug 2017
First published
02 Aug 2017

Chem. Commun., 2017,53, 9446-9449

Palladium-catalyzed aminocarbonylation of halo-substituted 7-azaindoles and other heteroarenes using chloroform as a carbon monoxide source

P. Kannaboina, G. Raina, K. Anil Kumar and P. Das, Chem. Commun., 2017, 53, 9446 DOI: 10.1039/C7CC04339B

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