Issue 73, 2017

Bio-catalytic nanocompartments for in situ production of glucose-6-phosphate

Abstract

Cells are sophisticated biocatalytic systems driving a complex network of biochemical reactions. A bioinspired strategy to create advanced functional systems is to design confined spaces for complex enzymatic reactions by using a combination of synthetic polymer assemblies and natural cell components. Here, we developed bio-catalytic nanocompartments that contain phosphoglucomutase protected by a biomimetic polymer membrane, which was permeabilized for reactants through insertion of an engineered α-hemolysin pore protein. These bio-catalytic nanocompartments serve for production of glucose-6-phosphate, and thus possess great potential for applications in an incomplete glycolysis, pentose phosphate pathway, or in plant biological reactions.

Graphical abstract: Bio-catalytic nanocompartments for in situ production of glucose-6-phosphate

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
18 Jun 2017
Accepted
22 Aug 2017
First published
22 Aug 2017

Chem. Commun., 2017,53, 10148-10151

Bio-catalytic nanocompartments for in situ production of glucose-6-phosphate

M. Lomora, G. Gunkel-Grabole, S. Mantri and C. G. Palivan, Chem. Commun., 2017, 53, 10148 DOI: 10.1039/C7CC04739H

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