Enhancing the solubility and bioactivity of anticancer drug tamoxifen by water-soluble pillar[6]arene-based host–guest complexation

Liqing Shangguan; Qi Chen; Bingbing Shi; Feihe Huang

doi:10.1039/C7CC05305C

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Enhancing the solubility and bioactivity of anticancer drug tamoxifen by water-soluble pillar[6]arene-based host–guest complexation†

Liqing Shangguan,^a Qi Chen,^a Bingbing Shi

^a and Feihe Huang

*^a

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* Corresponding authors

^a State Key Laboratory of Chemical Engineering, Center for Chemistry of High-Performance & Novel Materials, Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China
E-mail: fhuang@zju.edu.cn
Fax: +86-571-8795-3189
Tel: +86-571-8795-3189

Abstract

A water-soluble pillar[6]arene functions as a solubilizing agent to enhance the solubility and bioactivity of poorly water-soluble anticancer drug tamoxifen by host–guest complexation between it and tamoxifen.

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DOI: https://doi.org/10.1039/C7CC05305C
Article type: Communication
Submitted: 10 Jul 2017
Accepted: 07 Aug 2017
First published: 09 Aug 2017

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Chem. Commun., 2017,53, 9749-9752

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Enhancing the solubility and bioactivity of anticancer drug tamoxifen by water-soluble pillar[6]arene-based host–guest complexation

L. Shangguan, Q. Chen, B. Shi and F. Huang, Chem. Commun., 2017, 53, 9749 DOI: 10.1039/C7CC05305C

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Chemical Communications

Enhancing the solubility and bioactivity of anticancer drug tamoxifen by water-soluble pillar[6]arene-based host–guest complexation†

Abstract

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Enhancing the solubility and bioactivity of anticancer drug tamoxifen by water-soluble pillar[6]arene-based host–guest complexation

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