Issue 91, 2017

Programming membrane permeability using integrated membrane pores and blockers as molecular regulators

Abstract

We report a bottom-up synthetic biology approach to engineering vesicles with programmable permeabilities. Exploiting the concentration-dependent relationship between constitutively active pores (alpha-hemolysin) and blockers allows blockers to behave as molecular regulators for tuning permeability, enabling us to systematically modulate cargo release kinetics without changing the lipid fabric of the system.

Graphical abstract: Programming membrane permeability using integrated membrane pores and blockers as molecular regulators

Supplementary files

Article information

Article type
Communication
Submitted
13 Jul 2017
Accepted
16 Oct 2017
First published
01 Nov 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 12282-12285

Programming membrane permeability using integrated membrane pores and blockers as molecular regulators

J. M. Thomas, M. S. Friddin, O. Ces and Y. Elani, Chem. Commun., 2017, 53, 12282 DOI: 10.1039/C7CC05423H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements