Issue 81, 2017

Impact of cellular health conditions on the protein folding state in mammalian cells

Abstract

By using in-cell NMR experiments, we have demonstrated that the protein folding state in cells is significantly influenced by the cellular health conditions. hAK1 was denatured in cells under stressful culture conditions, while it remained functional and properly folded in cells continuously supplied with a fresh medium.

Graphical abstract: Impact of cellular health conditions on the protein folding state in mammalian cells

Supplementary files

Article information

Article type
Communication
Submitted
01 Aug 2017
Accepted
22 Sep 2017
First published
22 Sep 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 11245-11248

Impact of cellular health conditions on the protein folding state in mammalian cells

K. Inomata, H. Kamoshida, M. Ikari, Y. Ito and T. Kigawa, Chem. Commun., 2017, 53, 11245 DOI: 10.1039/C7CC06004A

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