Issue 83, 2017
From the journal:

Chemical Communications

A water-soluble two-photon ratiometric triarylboron probe with nucleolar targeting by preferential RNA binding†

Jun Liu, ORCID logo a   Shilu Zhang,a   Chenghua Zhang,a   Jun Dong,a   Chengyi Shen,a   Jiang Zhu, ORCID logo a   Huajun Xu,*b   Mingkai Fu,*c   Guoqiang Yang ORCID logo *d  and  Xiaoming Zhange  

* Corresponding authors

a Sichuan Key Laboratory of Medical Imaging & Department of Chemistry, School of Preclinical Medicine, North Sichuan Medical College, Nanchong, China
E-mail: ustbliujun@iccas.ac.cn

b Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China
E-mail: fromhjx@foxmail.com

c Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, China
E-mail: fumingkai@mail.iee.ac.cn

d Beijing National Laboratory for Molecular Sciences, Key laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
E-mail: gqyang@iccas.ac.cn

e Affiliated Hospital of North Sichuan Medical College, Nanchong, China

Abstract

By functionalizing triarylboron with cyclen, we developed a two-photon fluorescence probe, TAB-2, which can selectively bind RNA with a ratiometric readout. We tested TAB-2 in NIH/3T3 fibroblast cells, and demonstrated its capability in visualizing nucleoli and analyzing microenvironment polarity by two-photon and fluorescence-lifetime imaging microscopy.

Graphical abstract: A water-soluble two-photon ratiometric triarylboron probe with nucleolar targeting by preferential RNA binding

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Article information

DOI
https://doi.org/10.1039/C7CC06045A
Article type
Communication
Submitted
02 Aug 2017
Accepted
02 Oct 2017
First published
02 Oct 2017

Chem. Commun., 2017,53, 11476-11479

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A water-soluble two-photon ratiometric triarylboron probe with nucleolar targeting by preferential RNA binding

J. Liu, S. Zhang, C. Zhang, J. Dong, C. Shen, J. Zhu, H. Xu, M. Fu, G. Yang and X. Zhang, Chem. Commun., 2017, 53, 11476 DOI: 10.1039/C7CC06045A

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