Triazolium cyclodextrin click cluster–resin conjugate: an enrichment material for phosphatidylinositol (3,4,5)-triphosphate

H. T. Le; J. W. Lee; S. C. Park; J. W. Jeong; W. Jung; C. W. Lim; K. P. Kim; T. W. Kim

doi:10.1039/C7CC06151J

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Triazolium cyclodextrin click cluster–resin conjugate: an enrichment material for phosphatidylinositol (3,4,5)-triphosphate†

H. T. Le,

^a J. W. Lee,

^b S. C. Park,

^b J. W. Jeong,

^a W. Jung,^c C. W. Lim,

^d K. P. Kim

*^b and T. W. Kim

*^a

Author affiliations

* Corresponding authors

^a Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Republic of Korea
E-mail: tw1275@khu.ac.kr

^b Department of Applied Chemistry, College of Applied Science, Kyung Hee University, Yongin, Republic of Korea
E-mail: kimkp@khu.ac.kr

^c Department of Emergency Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea

^d Department of Chemistry, College of Life Science and Nano-technology, Hannam University, Daejeon, Republic of Korea

Abstract

UltraLink was functionalized with a triazolium cyclodextrin click cluster (CCC) which provides a well-oriented, multivalent, positively charged binding site for PtdIns(3,4,5)P₃. MALDI TOF MS and LC ESI MS/MS MRM analysis of spiked PtdIns(3,4,5)P₃ in lipid extract suggest that triazolium CCC–UltraLink conjugate can be used as an enrichment material for PtdIns(3,4,5)P₃.

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Article information

DOI: https://doi.org/10.1039/C7CC06151J
Article type: Communication
Submitted: 07 Aug 2017
Accepted: 04 Sep 2017
First published: 04 Sep 2017

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Chem. Commun., 2017,53, 10459-10462

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Triazolium cyclodextrin click cluster–resin conjugate: an enrichment material for phosphatidylinositol (3,4,5)-triphosphate

H. T. Le, J. W. Lee, S. C. Park, J. W. Jeong, W. Jung, C. W. Lim, K. P. Kim and T. W. Kim, Chem. Commun., 2017, 53, 10459 DOI: 10.1039/C7CC06151J

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Chemical Communications

Triazolium cyclodextrin click cluster–resin conjugate: an enrichment material for phosphatidylinositol (3,4,5)-triphosphate†

Abstract

Supplementary files

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Triazolium cyclodextrin click cluster–resin conjugate: an enrichment material for phosphatidylinositol (3,4,5)-triphosphate

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