Issue 98, 2017

Recent developments in transition-metal photoredox-catalysed reactions of carbonyl derivatives

Abstract

Single-electron reduction of C[double bond, length as m-dash]O and C[double bond, length as m-dash]N bonds of aldehydes, ketones, and imines results in the formation of ketyl and α-aminoalkyl anion radicals, respectively. These reactive intermediates are characterized by an altered electronic character with respect to their parent molecules and undergo a diverse range of synthetically useful transformations, which are not available to even-electron species. This Review summarizes the reactions of ketyl and α-aminyl radicals generated from carbonyl derivatives under transition-metal photoredox-catalysed conditions. We primarily focus on recent developments in the field, as well as give a brief overview of catalytic enantioselective transformations that provide a means to achieve precise stereocontrol over the reactivity of ion radicals.

Graphical abstract: Recent developments in transition-metal photoredox-catalysed reactions of carbonyl derivatives

Article information

Article type
Feature Article
Submitted
10 Aug 2017
Accepted
30 Oct 2017
First published
10 Nov 2017

Chem. Commun., 2017,53, 13093-13112

Recent developments in transition-metal photoredox-catalysed reactions of carbonyl derivatives

K. N. Lee and M. Ngai, Chem. Commun., 2017, 53, 13093 DOI: 10.1039/C7CC06287G

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