Issue 81, 2017
From the journal:

Chemical Communications

Nitric oxide-activatable gold nanoparticles for specific targeting and photo-thermal ablation of macrophages†

Junghong Park,ab   Swapan Pramanick,ab   Jinhwan Kim,ab   Jihyun Leeab  and  Won Jong Kim ORCID logo *ab  

* Corresponding authors

a Center for Self-assembly and Complexity, Institute for Basic Science, Pohang 790-784, Korea

b Department of Chemistry, Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Korea
E-mail: wjkim@postech.ac.kr

Abstract

In this study, we designed NO-activatable gold nanoparticles (NAM-AuNPs) for specific targeting and photo-thermal ablation of macrophages. The gold nanoparticles showed aggregation behavior in response to NO solution as well as endogenous NO secreted from activated macrophages. Following NIR irradiation, significant cytotoxicity was observed in activated RAW 264.7 cells treated with NAM-AuNPs.

Graphical abstract: Nitric oxide-activatable gold nanoparticles for specific targeting and photo-thermal ablation of macrophages

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Article information

DOI
https://doi.org/10.1039/C7CC06420A
Article type
Communication
Submitted
16 Aug 2017
Accepted
20 Sep 2017
First published
20 Sep 2017

Chem. Commun., 2017,53, 11229-11232

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Nitric oxide-activatable gold nanoparticles for specific targeting and photo-thermal ablation of macrophages

J. Park, S. Pramanick, J. Kim, J. Lee and W. J. Kim, Chem. Commun., 2017, 53, 11229 DOI: 10.1039/C7CC06420A

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