C(sp3)–H amination of 8-methylquinolines with azodicarboxylates under Rh(III) catalysis: cytotoxic evaluation of quinolin-8-ylmethanamines

Taejoo Jeong; Neeraj Kumar Mishra; Prasanta Dey; Hyunjung Oh; Sangil Han; Suk Hun Lee; Hyung Sik  Kim; Jihye Park; In Su Kim

doi:10.1039/C7CC06670H

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C(sp³)–H amination of 8-methylquinolines with azodicarboxylates under Rh(iii) catalysis: cytotoxic evaluation of quinolin-8-ylmethanamines†

Taejoo Jeong,^a Neeraj Kumar Mishra,^a Prasanta Dey,^a Hyunjung Oh,^a Sangil Han,^a Suk Hun Lee,^a Hyung Sik Kim,^a Jihye Park*^a and In Su Kim

*^a

Author affiliations

* Corresponding authors

^a School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea
E-mail: qkr3548@naver.com, insukim@skku.edu
Fax: +82 31 292 8800
Tel: +82 31 290 7788

Abstract

The rhodium(III)-catalyzed C(sp³)–H amination reaction of 8-methylquinolines and azodicarboxylates is described. A cationic rhodium catalyst in the presence of lithium acetate and lithium carbonate was found to be an optimal catalytic system for the construction of quinolin-8-ylmethanamine derivatives, which were evaluated for in vitro cytotoxicity against human breast adenocarcinoma cells (MCF-7) and human prostate adenocarcinoma cells (LNCaP).

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DOI: https://doi.org/10.1039/C7CC06670H
Article type: Communication
Submitted: 25 Aug 2017
Accepted: 21 Sep 2017
First published: 21 Sep 2017

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Chem. Commun., 2017,53, 11197-11200

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C(sp³)–H amination of 8-methylquinolines with azodicarboxylates under Rh(III) catalysis: cytotoxic evaluation of quinolin-8-ylmethanamines

T. Jeong, N. K. Mishra, P. Dey, H. Oh, S. Han, S. H. Lee, H. S. Kim, J. Park and I. S. Kim, Chem. Commun., 2017, 53, 11197 DOI: 10.1039/C7CC06670H

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