Issue 87, 2017
From the journal:

Chemical Communications

Palladium-catalyzed denitrogenative functionalizations of benzotriazoles with alkenes and 1,3-dienes†

Yuanhao Wang,a   Yuanhe Li, ORCID logo b   Yijun Fan,a   Zhiguo Wanga  and  Yefeng Tang ORCID logo *abc  

* Corresponding authors

a School of Pharmaceutical Sciences & Comprehensive AIDS Research Center, Tsinghua University, Beijing 100084, China
E-mail: yefengtang@tsinghua.edu.cn

b Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Beijing National Laboratory for Molecular Science, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

c Collaborative Innovation Center for Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Medical School, Sichuan University, Chengdu 610041, China

Abstract

Pd-Catalyzed denitrogenative functionalizations of benzotriazoles with alkenes and 1,3-dienes have been developed, which enable the rapid access of diverse ortho-amino styrenes and 2-vinylindolines, respectively. This study shows the great potential of benzotriazoles as a [1C]-synthon in cross-coupling reactions and an aza-[3C]-synthon in cycloaddition reactions.

Graphical abstract: Palladium-catalyzed denitrogenative functionalizations of benzotriazoles with alkenes and 1,3-dienes

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Article information

DOI
https://doi.org/10.1039/C7CC07543J
Article type
Communication
Submitted
27 Sep 2017
Accepted
09 Oct 2017
First published
10 Oct 2017

Chem. Commun., 2017,53, 11873-11876

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Palladium-catalyzed denitrogenative functionalizations of benzotriazoles with alkenes and 1,3-dienes

Y. Wang, Y. Li, Y. Fan, Z. Wang and Y. Tang, Chem. Commun., 2017, 53, 11873 DOI: 10.1039/C7CC07543J

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