Gold-catalyzed [2+2+2+2]-annulation of 1,3,5-hexahydro-1,3,5-triazines with alkoxyallenes

Abstract

An unprecedented gold-catalyzed [2+2+2+2]-annulation of 1,3,5-hexahydro-1,3,5-triazines with alkoxyallenes has been developed, providing eight-membered heterocycles in good to excellent yields. Deuterium labeling and control experiments reveal the possible reaction mechanism for this annulation.