Issue 100, 2017

Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines

Abstract

A carbene-catalyzed LUMO activation of α,β-unsaturated alkyne esters is reported. This catalytic process allows for effective reactions of alkyne esters with enamides to synthesize functional pyridines via simple protocols. A previously unexplored unsaturated alkyne acyl azolium intermediate is involved in the key step of the reaction.

Graphical abstract: Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines

Supplementary files

Article information

Article type
Communication
Submitted
18 Oct 2017
Accepted
20 Nov 2017
First published
21 Nov 2017

Chem. Commun., 2017,53, 13359-13362

Carbene-catalyzed LUMO activation of alkyne esters for access to functional pyridines

C. Mou, J. Wu, Z. Huang, J. Sun, Z. Jin and Y. R. Chi, Chem. Commun., 2017, 53, 13359 DOI: 10.1039/C7CC08039E

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