Synthesis and characterization of polyoxometalate-based silver(i) phenylethynide compounds with antibacterial and antifungal activities

Abstract

Six new silver-phenylethynide compounds, namely, [(AgCCPh)₄(AgCF₃SO₃)(DMSO)₂] (1), [(AgCCPh)(Ag₃PW₁₂O₄₀)(DMSO)₈] (2), [(AgCCPh)(Ag₃PMo₁₂O₄₀)(DMSO)₈] (3), [(AgCCPh)(Ag₄SiW₁₂O₄₀)(DMSO)₁₀] (4), [(AgCCPh)₈(Ag₄SiW₁₂O₄₀)(DMSO)₁₀] (5), and [(AgCCPh)₁₆(Ag₃PW₁₂O₄₀)(DMSO)₈(H₂O)₂] (6), have been synthesized and structurally characterized by X-ray crystallography. These compounds exhibit a coordinated silver column structure with OTf⁻/POM anions serving as counter-anions (1, 6), an infinite chain structure based on the coordinated Ag₄ aggregates and POM anions (2, 3) and a discrete molecular structure containing coordinated silver aggregates and POM anions (4, 5), respectively. The pure phases of 1–5 are obtained and identified. The antibacterial/antifungal activities of 1–5 are screened by the disk diffusion method against the bacteria strains Bacillus pumilus, Bacillus subtilis, Staphylococcus aureus and Escherichia coli and the fungi strains Aspergillus niger and Canidia albicans, and the MIC/MBC values are also measured. The cytotoxicity and biological toxicity test results showed that these compounds have low toxicity in both cells and animals.