Issue 27, 2017

Reducing a cocrystal to nanoscale dimensions enables retention of physical crystal integrity upon dehydration

Abstract

We report the preparation and dehydration of a cocrystal of caffeine and 2,4-dihydroxybenzoic acid. The dehydration of cocrystals of macro-dimensions results in destruction of crystal morphology; however, crystal morphology is retained when the cocrystal is reduced to nanometer-dimensions, despite a lack of pores to accommodate loss of water.

Graphical abstract: Reducing a cocrystal to nanoscale dimensions enables retention of physical crystal integrity upon dehydration

Supplementary files

Article information

Article type
Communication
Submitted
02 May 2017
Accepted
15 Jun 2017
First published
16 Jun 2017

CrystEngComm, 2017,19, 3723-3726

Reducing a cocrystal to nanoscale dimensions enables retention of physical crystal integrity upon dehydration

K. E. Peterson, R. F. Henry, G. G. Z. Zhang and L. R. MacGillivray, CrystEngComm, 2017, 19, 3723 DOI: 10.1039/C7CE00826K

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