Structural landscape of multicomponent solids of 5-aminosalicylic acid

Abstract

Crystallization of ten new multicomponent solids of 5-aminosalicylic acid with various inorganic and organic coformers has been achieved by mechanochemical and solvent evaporation techniques. The structural description of all the solids has been described in terms of robust ring motifs and supramolecular acid⋯pyridine synthons. The R⁴₄(12) motif is the key structural unit appearing in almost all the multicomponent solids formed in the presence of inorganic and organic acids and this is further verified with other related structures reported in the CSD database. The choice of a structural model between a cocrystal and a salt for the different solids was further ascertained by ATR study.