Growth mechanism study of clustered aggregates of dirithromycin crystals in N,N-dimethylformamide solvent

Abstract

A novel self-aggregated cluster of the pharmaceutical compound dirithromycin was observed through a solvent evaporation-induced method. The initial y-elongated hexagonal crystals experienced repeat attachment and growth process, according to the growth law of critical size λ and adsorption angle θ, to assemble such unique clustered aggregates. These results suggest that the solvent plays a critical role in the crystal growth of aggregated clusters of dirithromycin. The oriented attachment and the interaction between the solvent N,N-dimethylformamide (DMF) and the solute dirithromycin were used to rationalize the observed morphologies of the aggregates.