Herein we report on applications of fluorinated diazoalkanes in cycloaddition reactions, with the emphasis on studying subtle differences between diverse fluorinated diazo compounds. These differences led to two major synthetic protocols in batch and flow that allow the safe and scalable synthesis of fluoroalkyl-, sulfone-substituted pyrazolines.
K. J. Hock, L. Mertens, F. K. Metze, C. Schmittmann and R. M. Koenigs, Green Chem., 2017, 19, 905 DOI: 10.1039/C6GC03187K
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