Antipseudomonal activity enhancement of luminescent iridium(iii) dipyridylamine complexes under visible blue light†‡
E.
Sauvageot, 
a
M.
Elie,
a
S.
Gaillard,
*a
R.
Daniellou,
b
P.
Fechter,
cd
I. J.
Schalk,
cd
J.-L.
Renaud
*a
and
G. L. A.
Mislin
*cd
a
M.
Elie,
a
S.
Gaillard,
*a
R.
Daniellou,
b
P.
Fechter,
cd
I. J.
Schalk,
cd
J.-L.
Renaud
*a
and
G. L. A.
Mislin
*cd
Abstract
Cyclometallated iridium(III) dipyridylamine complexes present antibacterial activity against P. aeruginosa, a highly resistant pathogenic bacterium. This activity is increased when the complex is conjugated to biotin, a bacterial nutrient, and a MIC of 4 μM (4 μg mL−1) has been observed. The irradiation of P. aeruginosa cultures with blue LED light potentiates the anti-bacterial activities of these iridium(III) complexes when they are conjugated to a glycoside.
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