Issue 8, 2017
From the journal:

New Journal of Chemistry

De novo design of a hydrolytic DNA cleavage agent, mono nitratobis(phen)cobalt(ii) aqua nitrate complex†

Surbhi Sharma,a   Loic Toupetb  and  Farukh Arjmand ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India
E-mail: farukh_arjmand@yahoo.co.in
Tel: +91 5712703893

b Institut de Physique de Rennes, UMR 625, Université de Rennes 1, Campus de Beaulieu Bat. 11 A, 263 av. Général Leclerc, 35042 Rennes Cedex, France

Abstract

A new potent intercalating entity, mono nitratobis(1,10-phenanthroline)cobalt(II) aqua nitrate, was synthesized and crystallized in the monoclinic P21/n space group, containing hydrogen bond acceptor (O atoms) groups, which mediates the hydrolytic cleavage of plasmid pBR322 DNA. The kinetic aspects of DNA cleavage analyzed by the T4 DNA ligase assay are detailed.

Graphical abstract: De novo design of a hydrolytic DNA cleavage agent, mono nitratobis(phen)cobalt(ii) aqua nitrate complex

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Article information

DOI
https://doi.org/10.1039/C7NJ00563F
Article type
Letter
Submitted
16 Feb 2017
Accepted
01 Mar 2017
First published
02 Mar 2017

New J. Chem., 2017,41, 2883-2886

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De novo design of a hydrolytic DNA cleavage agent, mono nitratobis(phen)cobalt(II) aqua nitrate complex

S. Sharma, L. Toupet and F. Arjmand, New J. Chem., 2017, 41, 2883 DOI: 10.1039/C7NJ00563F

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