Development of a viscosity sensitive fluorescent probe for real-time monitoring of mitochondria viscosity†
Abstract
Using hemicyanine and carbazole as an acceptor and a donor, respectively, we designed and synthesized two new mitochondrial-targeted fluorescent viscosity probes (MHC-V1 and MHC-V2). The new probes were membrane-permeable and suitable for visualization of the changes of viscosity within the mitochondria of living cells.