Enzyme-coated Janus nanoparticles that selectively bind cell receptors as a function of the concentration of glucose

Gabriele Rucinskaite; Sebastian A. Thompson; Sureyya Paterson; Roberto de la Rica

doi:10.1039/C7NR00298J

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Enzyme-coated Janus nanoparticles that selectively bind cell receptors as a function of the concentration of glucose†

Gabriele Rucinskaite,^a Sebastian A. Thompson,^ab Sureyya Paterson^a and Roberto de la Rica

*^ac

Author affiliations

* Corresponding authors

^a Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, Technology and Innovation Centre, 99 George Street, Glasgow, Scotland, UK
E-mail: roberto.drica@uib.es

^b Department of Chemistry and Biochemistry, Hunter College – City University of New York, New York 10065, USA

^c Department of Chemistry, University of the Balearic Islands, Carretera de Valldemossa km 7.5, 07122 Palma de Mallorca, Illes Balears, Spain

Abstract

A method is proposed for controlling the number of nanoparticles bound to cell membranes via RGDS peptide–integrin interactions. It consists of propelling nanoparticles bearing the peptides with enzymes (glucose oxidase), which disrupts biomolecular interactions as a function of the concentration of enzyme substrate (glucose).

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Article information

DOI: https://doi.org/10.1039/C7NR00298J
Article type: Communication
Submitted: 13 Jan 2017
Accepted: 11 Apr 2017
First published: 12 Apr 2017
This article is Open Access

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Nanoscale, 2017,9, 5404-5407

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Enzyme-coated Janus nanoparticles that selectively bind cell receptors as a function of the concentration of glucose

G. Rucinskaite, S. A. Thompson, S. Paterson and R. de la Rica, Nanoscale, 2017, 9, 5404 DOI: 10.1039/C7NR00298J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Nanoscale

Enzyme-coated Janus nanoparticles that selectively bind cell receptors as a function of the concentration of glucose†

Abstract

Supplementary files

Article information

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Enzyme-coated Janus nanoparticles that selectively bind cell receptors as a function of the concentration of glucose

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