Issue 2, 2017

The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa

Abstract

The ‘perfect storm’ of increasing bacterial antibiotic resistance and a decline in the discovery of new antibiotics, has made it necessary to search for new and innovative strategies to treat bacterial infections. Interruption of bacterial cell-to-cell communication signalling (Quorum Sensing), thus neutralizing virulence in pathogenic bacteria, is a growing area. 2-Alkyl-4-quinolones, HHQ and PQS, play a key role in the quorum sensing circuitry of P. aeruginosa. We report a new set of isosteres of 2-heptyl-6-nitroquinolin-4-one, with alterations at C-3, and evaluate the key structural requirements for agonistic and antagonistic activity in Pseudomonas aeruginosa.

Graphical abstract: The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa

Supplementary files

Article information

Article type
Communication
Submitted
01 Sep 2016
Accepted
24 Nov 2016
First published
30 Nov 2016

Org. Biomol. Chem., 2017,15, 306-310

The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa

R. Shanahan, F. J. Reen, R. Cano, F. O'Gara and G. P. McGlacken, Org. Biomol. Chem., 2017, 15, 306 DOI: 10.1039/C6OB01930G

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