Silver-catalyzed C2-selective direct alkylation of heteroarenes with tertiary cycloalkanols

Abstract

A silver-catalyzed regioselective C2-alkylation of heteroarenes with tertiary cycloalkanols under radical conditions was developed. This tandem process, which includes selective C–H activation, C(sp³)–C(sp³) bond cleavage, and C(sp³)–C(sp²) bond formation, affords a novel and environmentally friendly approach for the production of carbonyl-containing alkyl-substituted heteroarenes with moderate to good yields.