An unnatural CDP-amino acid (kd) is used in the design and synthesis of novel cell penetrating peptidomimetic (Kkd-5). The balanced cationic nature and structural rigidity of Kkd-5 resulted in serum stability, non-toxicity to cells, and interaction with membrane and DNA, all of which facilitated efficient cellular uptake and DNA delivery.
C. Madhu, C. Voshavar, K. Rajasekhar and T. Govindaraju, Org. Biomol. Chem., 2017, 15, 3170 DOI: 10.1039/C7OB00167C
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