Issue 14, 2017

Palladium-catalyzed highly regioselective hydroaminocarbonylation of aromatic alkenes to branched amides

Abstract

Pd(t-Bu3P)2 has been successfully identified as an efficient catalyst for the hydroaminocarbonylation of aromatic alkenes to branched amides under relatively mild reaction conditions. With hydroxylamine hydrochloride as an additive, both aliphatic and aromatic amines could be used as coupling partners for the present reaction, leading to production of branched amides in high yields with excellent regioselectivities.

Graphical abstract: Palladium-catalyzed highly regioselective hydroaminocarbonylation of aromatic alkenes to branched amides

Supplementary files

Article information

Article type
Communication
Submitted
15 Feb 2017
Accepted
13 Mar 2017
First published
22 Mar 2017

Org. Biomol. Chem., 2017,15, 2910-2913

Palladium-catalyzed highly regioselective hydroaminocarbonylation of aromatic alkenes to branched amides

J. Zhu, B. Gao and H. Huang, Org. Biomol. Chem., 2017, 15, 2910 DOI: 10.1039/C7OB00371D

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