A water-soluble pillar[5]arene as a new carrier for an old drug

Lucia Barbera; Domenico Franco; Laura M. De Plano; Giuseppe Gattuso; Salvatore P. P. Guglielmino; Germana Lentini; Nadia Manganaro; Nino Marino; Sebastiano Pappalardo; Melchiorre F. Parisi; Fausto Puntoriero; Ilenia Pisagatti; Anna Notti

doi:10.1039/C7OB00530J

A water-soluble pillar[5]arene as a new carrier for an old drug†

Lucia Barbera,^a Domenico Franco,^a Laura M. De Plano,^a Giuseppe Gattuso,

^a Salvatore P. P. Guglielmino,^a Germana Lentini,^b Nadia Manganaro,^a Nino Marino,^c Sebastiano Pappalardo,

^d Melchiorre F. Parisi,

^a Fausto Puntoriero,^a Ilenia Pisagatti

*^a and Anna Notti

*^a

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* Corresponding authors

^a Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università di Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy
E-mail: anotti@unime.it, ipisagatti@unime.it

^b Dipartimento di Medicina Clinica e Sperimentale, Università di Messina, via Consolare Valeria 1, 98125 Messina, Italy

^c School of Biomedical Sciences, SAAD Ulster University, Cromore Road, BT521SA Coleraine, Northern Ireland, UK

^d Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, 95125 Catania, Italy

Abstract

The remarkable affinity of deca-carboxylatopillar[5]arene WP5 towards the aminoglycoside antibiotic, amikacin, in aqueous media is reported; in vitro studies on Gram-positive bacteria (Staphylococcus aureus) show that drug entrapment inside WP5 also takes place in the presence of the microrganisms, thus pointing to WP5 as an appealing carrier for amikacin targeted delivery.

Organic & Biomolecular Chemistry

A water-soluble pillar[5]arene as a new carrier for an old drug†

Abstract

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A water-soluble pillar[5]arene as a new carrier for an old drug

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