Issue 18, 2017

A highly selective and sensitive fluorescent probe for Cu2+ based on a novel naphthalimide–rhodamine platform and its application in live cell imaging

Abstract

Copper plays important roles in a variety of fundamental physiological processes. At the cell organelle level, aberrant copper homeostasis in lysosomes can lead to various serious diseases. Herein, a bifluorophore-based, lysosome-targetable Cu2+-selective ratiometric fluorescent probe (V) has been synthesized by reasonable design. The probe V shows high selectivity toward Cu2+ ions over other cations and exhibits high sensitivity (1.45 nM) for the detection of Cu2+ ions. Meanwhile, the probe is cell permeable and suitable for ratiometric visualization of lysosomal Cu2+ in the living cell.

Graphical abstract: A highly selective and sensitive fluorescent probe for Cu2+ based on a novel naphthalimide–rhodamine platform and its application in live cell imaging

Supplementary files

Article information

Article type
Paper
Submitted
03 Mar 2017
Accepted
11 Apr 2017
First published
12 Apr 2017

Org. Biomol. Chem., 2017,15, 3947-3954

A highly selective and sensitive fluorescent probe for Cu2+ based on a novel naphthalimide–rhodamine platform and its application in live cell imaging

C. Liu, X. Jiao, S. He, L. Zhao and X. Zeng, Org. Biomol. Chem., 2017, 15, 3947 DOI: 10.1039/C7OB00538E

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