Metal-free I2O5-mediated direct construction of sulfonamides from thiols and amines

Minghui Zhu; Wei Wei; Daoshan Yang; Huanhuan Cui; Leilei Wang; Guoqing Meng; Hua Wang

doi:10.1039/C7OB00668C

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Metal-free I₂O₅-mediated direct construction of sulfonamides from thiols and amines†

Minghui Zhu,^a Wei Wei,

*^a Daoshan Yang,^a Huanhuan Cui,^a Leilei Wang,^a Guoqing Meng^a and Hua Wang

*^a

Author affiliations

* Corresponding authors

^a Institute of Medicine and Material Applied Technologies, Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong, China
E-mail: weiweiqfnu@163.com, huawang_qfnu@126.com

Abstract

A simple and convenient method has been developed for the construction of sulfonamides via I₂O₅-mediated sulfonylation of amines with arylthiols. The present protocol provides an attractive approach to sulfonamides in moderate to good yields from readily accessible and easy to handle starting materials under mild and metal-free conditions.

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Article information

DOI: https://doi.org/10.1039/C7OB00668C
Article type: Communication
Submitted: 17 Mar 2017
Accepted: 10 May 2017
First published: 12 May 2017

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Org. Biomol. Chem., 2017,15, 4789-4793

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Metal-free I₂O₅-mediated direct construction of sulfonamides from thiols and amines

M. Zhu, W. Wei, D. Yang, H. Cui, L. Wang, G. Meng and H. Wang, Org. Biomol. Chem., 2017, 15, 4789 DOI: 10.1039/C7OB00668C

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Organic & Biomolecular Chemistry