Issue 19, 2017

Visible-light-induced and iron-catalyzed methylation of N-arylacrylamides with dimethyl sulphoxide: a convenient access to 3-ethyl-3-methyl oxindoles

Abstract

A visible-light-induced and iron-catalyzed methylation of arylacrylamides by dimethyl sulphoxide (DMSO) is achieved, leading to 3-ethyl-3-methyl indolin-2-ones in high yields. This reaction tolerates a series of functional groups, such as methoxy, trifluoromethyl, cyano, nitro, acetyl and ethyloxy carbonyl groups. The visible-light promoted radical methylation and arylation of the alkenyl group are involved in this reaction.

Graphical abstract: Visible-light-induced and iron-catalyzed methylation of N-arylacrylamides with dimethyl sulphoxide: a convenient access to 3-ethyl-3-methyl oxindoles

Supplementary files

Article information

Article type
Paper
Submitted
29 Mar 2017
Accepted
20 Apr 2017
First published
20 Apr 2017

Org. Biomol. Chem., 2017,15, 4205-4211

Visible-light-induced and iron-catalyzed methylation of N-arylacrylamides with dimethyl sulphoxide: a convenient access to 3-ethyl-3-methyl oxindoles

Z. Xie, P. Li, Y. Hu, N. Xu and L. Wang, Org. Biomol. Chem., 2017, 15, 4205 DOI: 10.1039/C7OB00779E

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